Description
Rooted in centuries of Japanese tradition and brought to modern attention through scientific discovery, our premium Nattokinase supplement is formulated for those seeking a natural approach to supporting cardiovascular and circulatory wellness. Nattokinase is derived from natto, a traditional fermented soybean food long consumed in Japan. In the 1980s, researcher Dr. Hiroyuki Sumi identified this unique enzyme while studying natto, observing its remarkable enzymatic activity related to the breakdown of fibrin, an insight that sparked global scientific and clinical interest.
AgeImmune Nattokinase provides 200 mg of high-purity Nattokinase standardized to 4,000 FU (Fibrinolytic Units), delivering clinically relevant enzymatic activity designed to support healthy circulation and vascular function.
Why It Was Created
Modern lifestyle patterns, sedentary behavior, stress load, inflammatory diets, metabolic strain — all influence vascular integrity and blood flow dynamics. Nattokinase was formulated as a foundational circulatory support tool within a broader functional medicine framework for cardiovascular resilience and healthy aging.
What Foundational System It Supports
- Vascular function
- Fibrin balance
- Circulatory efficiency
- Healthy aging pathways
Circulation is not just about the heart, it is about nutrient delivery, oxygen transport, mitochondrial efficiency, and cellular longevity.
How It Differs From Generic Alternatives
Many nattokinase products:
- Under-dose enzymatic activity
- Fail to standardize FU potency
- Combine with unnecessary fillers
- Do not disclose meaningful clinical strength
AgeImmune Nattokinase, imported from Japan, delivers 4,000 FU of standardized enzymatic activity in a clean, professional-grade format, without artificial additives or unnecessary excipients.
Formulated through clinical experience in functional medicine, this is not a commodity supplement, it is a targeted vascular support tool.
Here are five prominent benefits of Nattokinase:
- Cardiovascular Support: Nattokinase has fibrinolytic activity, which means it helps to break down fibrin, a protein involved in blood clot formation. By promoting healthy circulation and preventing excessive clotting, Nattokinase supports cardiovascular health and may reduce the risk of cardiovascular diseases like heart attacks and strokes.*
- Blood Pressure Regulation: Research suggests that Nattokinase may help to lower blood pressure by promoting the production of nitric oxide, a compound that relaxes blood vessels, thereby improving blood flow and reducing hypertension.*
- Anti-inflammatory Properties: Nattokinase exhibits anti-inflammatory effects by inhibiting the activity of certain inflammatory enzymes. This may help reduce inflammation throughout the body, contributing to overall health and well-being.*
- Enhanced Circulation: By breaking down fibrin and supporting blood vessel health, Nattokinase improves circulation, which can alleviate symptoms of poor circulation such as cold hands and feet, leg cramps, and varicose veins.*
- Improved Immune Function: Some studies suggest that Nattokinase may enhance immune function by modulating immune responses and reducing oxidative stress. This can help the body better defend itself against infections and diseases, promoting overall immune health.*
Why This Form Was Chosen
- Standardized to 4,000 FU for meaningful enzymatic activity
- Clinically relevant potency
- Professional-grade purity
- Clean-label manufacturing
Standardization matters. Without FU measurement, potency is unknown. Healthy circulation supports mitochondrial ATP production by improving oxygen and nutrient availability at the cellular level.
Nattokinase works best when viewed as part of a foundational cardiovascular stack, alongside magnesium, vitamin D/K2, omega-3s, and metabolic support nutrients.
For deeper clinical discussion, see: Nattokinase Category Articles
Frequently Asked Questions
What does nattokinase support?
Nattokinase supports healthy blood flow, balanced fibrin activity, and vascular flexibility as part of overall cardiovascular wellness.
How is AgeImmune Nattokinase different from other brands?
It is standardized to 4,000 FU of enzymatic activity, ensuring meaningful potency rather than relying on unspecified dosing.
Can nattokinase be stacked with other supplements?
Yes. It is often combined with magnesium, vitamin D3 + K2, omega-3s, and metabolic support nutrients within a functional cardiovascular protocol.
When should I take nattokinase?
It is commonly taken on an empty stomach to optimize enzymatic activity, but follow guidance from your healthcare provider.
How long does it take to notice benefits?
Supportive effects on circulation may vary by individual. Many users integrate it as part of a long-term cardiovascular wellness strategy.
Is nattokinase safe for long-term use?
When used appropriately, nattokinase is generally well tolerated. Individuals on anticoagulants or with medical conditions should consult their healthcare provider before use.
Who should speak with a provider before taking nattokinase?
Those taking blood thinners, preparing for surgery, pregnant or breastfeeding individuals, or anyone under medical supervision should consult a licensed healthcare professional.
Our Nattokinase is made Without Magnesium Stearate | Silica | Silicon Dioxide | Non-GMO | Vegan | Dairy Free | Nut Free | Gluten & Wheat Free | Corn Free | Celiac Friendly | Made in a cGMP Facility
Supplement Facts:
Serving size: 2 capsules daily
Servings per container: 60
Nattokinase – 200mg (4000FU)
Other Ingredients: Cellulose (Vegetarian Capsule Shell), Organic Rice Concentrate, Contains Soy
Loyiz Suzzi –
Nattokinase has a unique characteristic of being easily broken down by stomach acids, which can reduce its effectiveness. That’s why this version, in delayed-release capsules, is ideal as it should pass through the stomach without breaking down. Overall, a solid product.
Yanina V –
I opted for Nattokinase from AgeImmune because it has no fillers. I always pay attention what other ingredients are there in a product.
Zina Z –
I was doing my homework on things to give me more energy and flexibility, and an overall better lifestyle, and this is when I learned that Japanese (who are famous for their life longevity and stability) use a diet full of fish oil and Natto soy.
I used to take fish oil supplements but decided to try Nattokinase, which combines both elements so common in Japanese culture.
After a few months, I can say I definitely feel the difference in my energy and skin!
Cormell R –
This supplement is simple to take and high quality.
It comes in a sealed bottle with 120 small veggie capsules that are easy to swallow. I appreciate the generous amount of nattokinase included, along with the delayed release feature, which makes it effective throughout the day.
Motunrayo –
This product has been highly beneficial for my health.Nattokinase, an enzyme extracted from natto—a traditional Japanese fermented soy dish—offers potential benefits for cardiovascular wellness. Overall, this nattokinase supplement is an excellent option for me as I’m looking to take advantage of the health benefits of this natural enzyme. It gets top marks from me!
Irina –
This one is from Japan. My whole family is taking Nattokinase. My husband went from 2000 fu to 4000 fu in a course of a year. I’ve done a lot of research on it and on the brands that are the major players on the market. While most of the supplements are encapsulated in the USA, raw ingredients are always foreign. AgeImmune’ Nattokinase is from Japan, that’s why I stopped searching and researching. Never experienced any side effects with the product.
And! They pick up the phone! Excellent customer service.
Shawn GF –
So far it works well. THIS WAS RECOMMENDED BY A DOCTOR I WAS SEEING FOR MY KNEE. HE TOLD ME IT WAS HELPFUL IN BREAKING UP CALCIFICATION DEPOSITS IN THE BODY. WHEN HE DID X-RAYS, IT DID LOOK LIKE THE PREVIOUS DEPOSITS HAD GOTTEN MUCH SMALLER AND NOT DENSE. I AM PLEASED WITH WHAT I SAW ON MY X-RAYS.
Bears M –
Good Stuff. This and nitric oxide and I’m off my bp meds. Feel great
Jessica C –
This product exceeded my expectations. This helps with circulation and cleaning up your circulatory system what a great product
Learned O –
Highly recommend. Recommended by Dr David Sinclair at Harvard. I feel it is really helpful.
William –
I highly recommend to use a supplement. It helps with blood thinning and clearing arteries, lowering cholesterol.